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EVATOCIN  FOETOCIN  GYNOTOCIN  INDOX  ITOCIN  NITOCIN  OXYBRO INJ  OXYSTAR  OXYTOCIN INJ  OXYTON-5  SAYTOCIN  SYNTOCINON 
 



Indication & Dosage
 
 
Intravenous
MISSED ABORTIONS
Adult: 10-100 milliunits/minute via IV infusion. Max: 30 units in a 12-hr period.
 
Intravenous
INDUCE ABORTION AFTER RUPTURE OF MEMBRANES
Adult: 10-100 milliunits/minute via IV infusion. Max: 30 units in a 12-hr period.
 
Intravenous
PREVENTION OF POSTPARTUM HAEMORRHAGE
Adult: 5 units by slow inj followed by IV infusion of 5-30 units in 500 ml of a suitable nonhydrating diluent at a rate to control uterine atony.
 
Intravenous
POSTPARTUM HAEMORRHAGE
Adult: 5 units by slow inj followed by IV infusion of 5-30 units in 500 ml of a suitable nonhydrating diluent at a rate to control uterine atony.
 
Oral
INDUCTION OF LABOUR FOR MEDICAL REASONS, HYPOTONIC UTERINE INERTIA
Adult: 1-2 milliunits/minute, may increase at intervals of 30-60 min until a max of 3-4 contractions occur every 10 minutes. Max: 32 milliunits/minute and not more than 5 units in 1 day. Not to be given within 6 hr after admin of vaginal prostaglandins.
 
Intravenous
OXYTOCIN CHALLENGE TEST FOR EVALUATING OF FOETAL DISTRESS
Adult: Dilute 5–10 units in 1 L of 5% dextrose inj. Initially, administer the drug in the mother via IV infusion at a rate of 0.5 milliunits/minute. May gradually increase infusion rate at intervals of 15-30 minutes. Max: 20 milliunits/minute. Monitor foetal heart rate and uterine contractions immediately before and during infusion. Discontinue infusion when 3 moderate uterine contractions occur within one 10-minute interval. Compare baseline and oxytocin-induced foetal heart rates. If no change occurs, repeat the test in 1 wk. Termination of pregnancy may be required if a late deceleration in foetal heart rate occurs.
 
Intramuscular
CAESAREAN SECTION
Adult: 10 units after delivery of the placenta.
 
Intravenous
PREVENTION OF POSTPARTUM HAEMORRHAGE
Adult: 5 units given with 500 mcg ergometrine maleate with or after delivery of the baby's shoulders.
 
Nasal
FACILITATE LACTATION
Adult: 1 spray (4 units) into 1 nostril 5 minutes before suckling.
   
Precautions CV disorders; >35 yr; lactation. Monitor foetal and maternal heart rate, maternal BP and uterine motility. Monitor fluid intake and output during treatment. Discontinute immediately if the uterus is hypertonic or hyperactive or if there is foetal distress. Use of nasal spray may produce maternal dependence on its effects. IM admin not regularly used due to unpredictable effects of oxytocin. Not to be used for prolonged periods in resistant uterine inertia, severe pre-eclampsia, or severe CV disorders. Risk of water intoxication when used at high doses for prolonged periods.
   
Potentially Life-threatening 
Adverse Drug Reactions
Foetus or neonate: Jaundice; arrhythmias, bradycardia; brain, CNS damage; seizure; retinal haemorrhage; low Apgar score. Mother: transient hypotension, reflex tachycardia; nasal irritation, rhinorrhoea, lachrymation (following nasal admin); uterine bleeding, violent contractions, hypertonicity; spasm; nausea, vomiting.
   
Adverse Drug Reactions Maternal water intoxication (especially with slow infusion over 24 hr); prolonged uterine contractions causing foetal hypoxia and death; rupture of gravid uterus; afibrinogenaemia; subarachnoid haemorrhage
   
Interactions Possible severe hypertension if given within 3-4 hr of vasoconstrictor in association with a caudal block anaesthesia. Cyclopropane anaesthesia may increase risk of hypotension and maternal sinus bradycardia with abnormal AV rhythms. Dinoprostone and misoprostol may increase uterotonic effect of oxytocin, thus oxytocin should not be used within 6 hr after admin of vaginal prostaglandins. Concurrent use may increase the vasopressor effect of sympathomimetics.
   
   
 

 

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